Telmisartan

Hypertension

Indicated for treatment of hypertension

Dosage must be individualized

40 mg/day PO initially; titrated to 20-80 mg/day PO, depending on response; patients with volume depletion should receive the lower dosage initially, under close supervision

Most of the antihypertensive effect is apparent within 2 weeks and maximal reduction is generally attained after 4 weeks

When additional blood pressure reduction is required after the 80-mg dose, a diuretic may be added

Cardiovascular risk reduction

Indicated for cardiovascular (CV) risk reduction in patients unable to take ACE inhibitors

80 mg PO qDay

Unknown whether doses lower than 80 mg are effective in reducing the risk of cardiovascular morbidity and mortality

Dosage Modifications

Renal impairment: No dosage adjustment necessary; hemodialysis (HD) patients at risk for orthostatic hypotension

Hepatic impairment

• In patients with hepatic insufficiency, plasma concentrations of telmisartan increased, and absolute bioavailability approached 100%
• Monitor carefully and titrate up slowly in patients with biliary obstructive disorders or hepatic insufficiency

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